Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department

• Status: Terminated
• Trial end date: 2018-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain associated with sickle cell disease is a common emergency department visit. It is also frequently associated with a high emergency department recidivism rate for pain control and admissions to the hospital. Opiates are considered the first line therapy for acute flares and to manage chronic pain. This often times leads to a stigma of being "opiate seekers" or "frequent fliers". With this study, we wish to explore whether adding ketamine to standard acute opiate therapy (morphine or dilaudid) will decrease subsequent repeat doses of opiates while improving the patient's perception of pain. In addition, we will be exploring whether ketamine as an adjuvant therapy can help reduce hospital admissions for the management of acute sickle cell crisis pain.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Billy Sin
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Patients 18 years old and older presenting with acute sickle cell crisis pain either described as diffuse throughout the body or localized to joint/extremity/back

• Describes pain to be greater than or equal to 2 on the NRS

• Consents to IV access

• Provides informed consent

Exclusion Criteria:

• Receiving IM therapy only

• Standard therapy plan is not morphine or dilaudid

• Previous enrollment in study

• Documented fever or subjectively reported fever

• Complaint of chest pain or shortness of breath or abdominal pain or headache

• Suspicion for acute chest crisis

• Patients with history or acute diagnosis of subarachnoid hemorrhage/increased intracranial pressure

• Severe hypertension(≥180/100)

• History of CAD or hypertension

• Presence of/suspected for traumatic head injury with or without loss of consciousness

• Presence of/suspected for myocardial ischemia

• Presence of/suspected for alcohol intoxication

• Hemodynamic instability

• History of psychiatric disorders,

• Known or suspected pregnancy or breastfeeding

• Allergy to ketamine

• Administration of opioids in previous 4 hours

• Patients with language barriers

• Ilicit drug use within the past 7 days