Ketamine Infusions for PTSD and Treatment-Resistant Depression
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
The relationship between depression and trauma is well established. Co-occuring depression
and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower
levels of functioning. Veterans with both depression and PTSD have been shown to be at much
higher risk of suicide than individuals with only one of these disorders. Ketamine has been
shown to have rapid antidepressant effects and also therapeutic action over PTSD symptoms.
The purpose of this study is to see whether ketamine, when given as repeated infusions, can
produce quick and sustained improvement in depression and PTSD symptoms for individuals who
have not had their symptoms effectively treated by current treatments.
Phase:
Phase 1
Details
Lead Sponsor:
Minneapolis Veterans Affairs Medical Center
Treatments:
Anesthetics Central Nervous System Depressants Excitatory Amino Acid Antagonists Excitatory Amino Acids Ketamine Molecular Mechanisms of Pharmacological Action Peripheral Nervous System Agents