Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection

• Status: Completed
• Trial end date: 2017-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Lidocaine and ketamine both are being used for perioperative analgesia. Perioperative lidocaine infusion has been shown to reduce postoperative pain and opioid consumption. Perioperative low dose Ketamine has shown improved postoperative pain and reduced opioid usage. We therefore tested the hypothesis that the combination would provide better analgesia in the milieu of intrathecal morphine.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Treatments: Ketamine; Lidocaine

Criteria

Inclusion Criteria:

• ASA physical status 2-4

• Elective major liver resection

• Signed informed consent

Exclusion Criteria:

• ICU admission after surgery

• tracheal extubation not planned after surgery

• language barrier

• mental impairment

• severe coagulopathy

• chronic pain or opioid dependance or both

• alcohol/substance abuse

• allergy to the study drugs

• refusal for spinal

• infection at site of spinal