Ketamine Patient-Controlled Analgesia for Acute Pain
Status:
Terminated
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
This study will compare ketamine and hydromorphone as alternative patient-controlled
interventions for trauma-related pain. Patients receiving ketamine PCA are expected to
require less total and breakthrough opioid and to have similar or improved objective pain
scores. Patients receiving ketamine are also expected to have shorter duration of
supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary
toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is
further expected to be associated with decreased intensive care unit and hospital lengths of
stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and
lower report of chronic pain syndromes.