Ketamine Pharmacokinetics in Children Having Heart Surgery
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
What are the pharmacokinetics of ketamine in infants and children requiring ketamine for
induction of anesthesia for cardiac surgery that requires CPB? Specific Aim 1: To determine
the pharmacokinetic parameters of a single intravenous bolus dose of ketamine in infants and
children undergoing cardiac surgery with and without CPB (cardio-pulmonary bypass).
Specific Aim 2: To describe the disposition of ketamine's primary active metabolite,
norketamine,following a single intravenous bolus dose of ketamine in infants and children
undergoing cardiac surgery with and without CPB.
Specific Aim 3: To determine the relationship between ketamine and norketamine
pharmacokinetic parameters and age as well as CPB time.