Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

• Status: Completed
• Trial end date: 2018-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis of this study is that a Ketamine / Propofol mixture will produce more stable hemodynamics as compared to Etomidate during emergent intubations in the intensive care unit. Patients that require a breathing tube to be placed in the ICU will be randomized to receIve either a Ketamine / Propofol mixture or Etomidate for sedation in order to place the breathing tube.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Etomidate; Ketamine; Propofol

Criteria

Inclusion Criteria:

• 18 years of age or older

• Surgical or medical intensive care unity patients requiring endotracheal intubation

• Consulting physician agrees to study plan and will follow drug randomization

Exclusion Criteria:

• Known intracranial pathology

• Known chronic opiate-dependence

• Received continuous sedative infusion in the last 24 hours

• Known severe psychiatric illness

• Known egg allergies

• Known contraindication to fentanyl, midazolam, ketamine, propofol or etomidate

• Intubation in which standard practice is not to use sedation

• No known documented weight or weight greater than 140 kg or less than 30 kg

• Prior participation in the study

• Of childbearing age (18-50) with no known negative pregnancy test on this admission.