Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity

• Status: Completed
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The expected benefit is a reduction of the morbidity of patients admitted in the intensive care unit having received ketamine for intubation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Etomidate; Ketamine

Criteria

Inclusion Criteria:

• Patient requiring sedation for prehospital endotracheal intubation

• Age ≥ 18 years

• Consent of a family member if present, then of the patient for the pursuit of research

Exclusion Criteria:

• Patient in cardiac arrest

• Presence of contraindication to succinylcholine:

• Personal or familial history of malignant hyperthermia

• Known hypersensitivity to succinylcholine

• Skeletal muscle disease

• Myasthenia

• Known hyperkalemia

• Severe ophthalmic injury

• Known congenital deficit in plasmatic pseudo-cholinesterase

• Presence of contraindication to ketamine:

• Known hypersensitivity to ketamine

• Known porphyria

• Severe hypertension

• Presence of contraindication to etomidate:

• Known untreated adrenal insufficiency

• Known hypersensitivity to etomidate

• Known pregnancy

• Unaffiliated patient to the social insurance