Ketamine Versus Fentanyl as an Adjunct to Propofol-Assisted Emergency Department Procedural Sedation
Status:
Completed
Trial end date:
2006-08-01
Target enrollment:
Participant gender:
Summary
We, the investigators at Queen's University, propose to conduct a randomized, double-blind,
feasibility trial comparing low-dose ketamine versus fentanyl as adjuncts to Emergency
Department procedural sedation with propofol. The outcomes of interest will be safety, with
respect to hemodynamic and respiratory adverse effects, as well as efficacy, with respect to
adequacy of sedation and analgesia, recovery profiles and patient/physician satisfaction. Our
hypothesis, based on a review of existing anesthesia literature, is that low-dose ketamine
may be a safer and more efficacious alternative to fentanyl when used as an adjunct to
propofol-assisted procedural sedation.