Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled Trial

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study will enroll patients presenting to the emergency department with acute suicidal ideation meeting inclusion and exclusion criteria. Patients will be randomized to one of three arms: ketamine (intervention) or diphenhydramine (control) or placebo (control). Serial measurements will be made in the ED and at follow-up intervals.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brooke Army Medical Center
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Patients age 18 to less than 75 who present to the SAMMC ED with either overt or incidental suicidal ideations with a SADPERSONS score 5 or greater that the treating provider feels warrant formal evaluation.

Exclusion Criteria:

• -Poor vital sign stability hypoxia: O2 < 95%, hypotension: SBP< 90 hypertension:

SBP>180 Heart rate: < 50 or >120 Respiratory Rate: <10 or >30

• Altered mental status or intoxication

• Patient is unwilling to participate or provide informed consent

• Any allergy to ketamine or diphenhydramine

• Patient is female of child-bearing age and unwilling to provide urine or blood for HCG analysis

• Pregnancy or breast feeding

• Presence of chronic oxygen-dependent pulmonary disease, liver cirrhosis, or renal disease requiring dialysis

• Presence of ischemic heart disease, heart failure, or a history of unstable dysrhythmias

• Presence of intracranial mass or vascular lesion.

• Presence of a history of psychosis or hallucinations (as assessed by electronic chart review)

• Weight greater than 115 kg or less than 45kg

• History of increased intracranial pressure/hypertensive hydrocephalus

• Non-English speaking patients

• Patient is acutely psychotic

• Provider feels that patient currently or likely will require chemical and/or physical restraints

• History of prolonged QT-interval