This is a pilot, double-blind, placebo-controlled randomized clinical trial of individuals
with opioid use disorder (OUD) with suicidal ideation in the emergency department (ED) to
receive either a single infusion of ketamine 0.8mg/kg (n=25) or saline placebo (n=25). The
primary aim is to evaluate the safety of the ketamine treatment. The secondary aim is to
determine the preliminary efficacy of opioid- and suicide-related outcomes.