Ketamine v. Ketorolac for Management of Generalized Tension Type Headache
Status:
Unknown status
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
The hypothesis of the study is that sub-dissociative dose ketamine will prove to be superior
to or as standard therapy, ketorolac, in the treatment of acute tension type headache (TTH)
as measured by the 10 point Numerical Rating Scale (NRS. The aim of the study is to compare
the safety & efficacy of intravenous sub-dissociative dose ketamine versus ketorolac for
acute treatment of migraines in the Emergency Department (ED) The primary endpoints are:
Patient perception of pain as described by the use the Numerical Rating Scale (NRS) at 30
minutes.
The secondary endpoints are: Frequency and mean dose of rescue/additional doses of therapy at
15, 30, 45, 60, 75, 90 min, Number of emergency department re-visits for acute migraine one
month post discharge, incidence of dissociative effects (characterized by hallucination,
disorientation, confusion, agitation, delirium, dreams) during study period, incidence of
nausea, vomiting, or worsening headache, Incidence of bad taste, Incidence of burning
sensations in the nostrils, incidence of hypertension, time to patient discharge from the
initiation of study medication/placebo, patient satisfaction of pain control based on a
Likert Scale.