Ketamine's Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway
Status:
Unknown status
Trial end date:
2018-11-01
Target enrollment:
Participant gender:
Summary
The kynurenine pathway is involved in hyperalgesia. This pathway is activated by
inflammation. Ketamine would interact with the kynurenine pathway and inflammation. Our
working hypotheses are: the clinical effects of ketamine on neuropathic pain are greater in
the presence of systemic inflammation and the mechanism of action involves an interaction on
the kynurenine pathway.
Study design: Interventional randomized placebo-controlled clinical trial.
Main goals:
1. To show a better clinical efficacy of ketamine in chronic pain in patients with an
inflammatory component.
2. Explore the anti-inflammatory activity of ketamine through the Kynurenine pathway.
Phase:
Phase 3
Details
Lead Sponsor:
Redar
Collaborators:
Fondation Apicil Hopital Lariboisière Hôpital Raymond Poincaré Hospital Ambroise Paré Paris Institut National de la Santé Et de la Recherche Médicale, France Recherche Clinique Paris Descartes Necker Cochin Sainte Anne