Ketoconazole, Hydrocortisone, and GM-CSF in Treating Patients With Progressive Prostate Cancer After Hormone Therapy
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as
ketoconazole, may stop the adrenal glands from making androgens. GM-CSF may help ketoconazole
work better by making tumor cells more sensitive to the drug. Giving ketoconazole together
with hydrocortisone and GM-CSF may be an effective treatment for prostate cancer.
PURPOSE: This phase II trial is studying how well giving ketoconazole together with
hydrocortisone and GM-CSF works in treating patients with progressive prostate cancer after
hormone therapy.