Ketofol Versus Fenofol as Procedural Sedation for Carpal Tunnel Release

• Status: Recruiting
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

There are different methods of anesthesia for CTR surgery. Procedural sedation will allow rapid recovery and fewer complications than regional or general anesthesia (GA).

Attempts have been made in the past to use additives with propofol to reduce its dose. Ketofol (ketamine/propofol combination) was used for procedural sedation and analgesia. Ketamine and propofol administered in combination have offered effective sedation for spinal anesthesia and for gynecologic, ophthalmologic, and cardiovascular procedures in all age groups. The opposing hemodynamic and respiratory effects of each drug may enhance the utility of this drug combination, increasing both safety and efficacy and allowing reduction in the dose of propofol required to achieve sedation.

Propofol alone had a significantly greater number of apnea with desaturation (SpO2 < 90%) episodes. Further, it has been shown that during colonoscopies, propofol in combination with fentanyl provided similar patient satisfaction with shorter recovery times even at lower depths of sedation as compared to propofol. The addition of fentanyl to propofol has been shown to result in better operator feasibility with no difference in recovery time, cognitive impairment, or complications as compared to the use of propofol only for sedation.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zagazig University
• Treatments: Fentanyl; Ketamine; Propofol

Criteria

Inclusion Criteria:

• Age: 21-55 years old.

• Sex: both sex (males or females).

• Physical status: ASA I & II.

• BMI: 25-30 kg/m2.

• Type of operation: elective unilateral CTR under local anesthesia.

• Written informed consent from the patient.

• Cooperative patient.

Exclusion Criteria:

• Patient refusal.

• Altered mental status.

• Patients with known history of allergy to study drugs.

• Severe hepatic, renal, Cardiovascular and respiratory diseases.

• Patients on regular sedative or pain killer medications.