Ketofol Versus Fenofol as Procedural Sedation for Carpal Tunnel Release
Status:
Recruiting
Trial end date:
2021-05-01
Target enrollment:
Participant gender:
Summary
There are different methods of anesthesia for CTR surgery. Procedural sedation will allow
rapid recovery and fewer complications than regional or general anesthesia (GA).
Attempts have been made in the past to use additives with propofol to reduce its dose.
Ketofol (ketamine/propofol combination) was used for procedural sedation and analgesia.
Ketamine and propofol administered in combination have offered effective sedation for spinal
anesthesia and for gynecologic, ophthalmologic, and cardiovascular procedures in all age
groups. The opposing hemodynamic and respiratory effects of each drug may enhance the utility
of this drug combination, increasing both safety and efficacy and allowing reduction in the
dose of propofol required to achieve sedation.
Propofol alone had a significantly greater number of apnea with desaturation (SpO2 < 90%)
episodes. Further, it has been shown that during colonoscopies, propofol in combination with
fentanyl provided similar patient satisfaction with shorter recovery times even at lower
depths of sedation as compared to propofol. The addition of fentanyl to propofol has been
shown to result in better operator feasibility with no difference in recovery time, cognitive
impairment, or complications as compared to the use of propofol only for sedation.