Ketofol Versus Propofol in Urgent ERCP for Acute Cholangitis

• Status: Recruiting
• Trial end date: 2021-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a lengthy and uncomfortable procedure that requires adequate sedation. Propofol is the commonly used sedative during ERCP. However, dose dependent cardiac and respiratory depression may occur. Hypotension usually occurs in severe cholangitis which necessitate the use of alternative sedative. The aim is to study the efficacy and safety of ketofol as a sedative during urgent ERCP for severe cholangitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Ketamine; Propofol

Criteria

Inclusion Criteria:

• Severe acute cholangitis of either sex

• Aged between 21-70 years

• Undergoing urgent therapeutic ERCP for severe cholangitis with American Society of Anaesthesiologist (ASA) Grade II - III.

Exclusion Criteria:

• Patients who had ASA physical status Grade VI,

• Baseline SpO2 <90%,

• Patients who had difficulty in communication,

• Patients allergic to the studied medications,

• Morbidly obese patients,

• Patients with chronic obstructive pulmonary disease,

• Complicated airway,

• Pregnant patients.