Ketofol for Preventing Postoperative Delirium in Elderly Patients
Status:
Recruiting
Trial end date:
2021-10-12
Target enrollment:
Participant gender:
Summary
- Delirium is a cognitive disturbance characterized by acute and fluctuating impairment in
attention and awareness. Although its incidence in the general surgical population is
2-3%, it has been reported to occur in up to 10-80% of high-risk patient groups. In
addition, the occurrence of postoperative delirium is associated with considerably
raised morbidity and mortality and increased healthcare resource expenditure.
- In the general patient population, no prophylactic pharmacologic treatment has shown
widespread effectiveness in preventing delirium. Several studies have failed to find a
magic pharmacologic bullet for preventing delirium-ketamine, haloperidol, propofol,
antipsychotic and benzodiazepine drugs have recently tested without a clear result of
its effectiveness.
- Dexmedetomidine is an attractive pharmacologic option because of its biological
plausibility in modifying several known contributors to delirium.
- Up to investigators' knowledge, there is no study done to compare the effect of infusion
of dexmedetomidine and ketofol mixture as prophylactic agents for high-risk patients as
elderly patients who undergoing high-risk surgery such as intestinal obstruction surgery
against postoperative delirium occurrence.