Ketorolac Plus Tobramycin/Dexamethasone Versus Tobramycin/Dexamethasone After Uneventful Phacoemulsification Surgery
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
This randomized controlled trial compares two regimens of topical therapy:
- tobramycin 0.3% - dexamethasone 0.1% (TobraDex®, Alcon), one drop four times/day
- combination of tobramycin 0.3% - dexamethasone 0.1% (TobraDex®, Alcon), one drop four
times/day, plus Ketorolac tromethamine 0.5% (Acular®, Allergan), one drop three
times/day.
Patients are independently assessed by two ophthalmologists. On days 7,14,21,28 patients are
evaluated for
- corneal edema
- conjunctival hyperemia
- anterior chamber (Tyndall) reaction.
The investigators purpose was to evaluate the benefit of adding a non-steroid agent to an
antibiotic/steroid combination after uneventful phacoemulsification. Adopting a weekly
follow-up, to gain insight into the optimal duration of postoperative treatment and to
examine whether risk factors for inflammation exist.