Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain

• Status: Not yet recruiting
• Trial end date: 2026-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will contribute to the current literature that have compared joint injections with steroid versus ketorolac providing evidence for the use of ketorolac for SI joint pain. Currently steroid is the clinical standard for joint injections, however with repetitive use, steroid injections can damage the joint. Ketorolac is an alternative anti-inflammatory medication that does not cause the same joint damage and at a cheaper cost than steroid. The investigators hypothesize that ultrasound guided SI joint injections utilizing ketorolac provide the same pain relief as corticosteroid SI joint injections measured at 2, 6 and 12 weeks post injection. This would allow more frequent injections to control pain at a decreased cost to the healthcare system.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: McMaster University
• Treatments: Ketorolac; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• SI joint pain for at least 3 months

• Age greater than 18

• Must have at least 3 special tests positive for SI joint pain on physical exam

Exclusion Criteria:

• Previous back surgery

• Radicular leg pain

• Discogenic pain

• Myofascial pain syndrome

• Depression

• Systemic infection or localized infection at anticipated needle entry sites

• Cognitive impairment preventing informed consent or accurate collection of data

• Patient allergic to medication used

• NSAID contraindications including:

• Gastrointestinal bleeds

• Renal failure

• Symptomatic congestive heart failure

• Cirrhosis