L-Arginine Supplementation and Exercise; L-Arginine Supplementation and Renal Function

• Status: Completed
• Trial end date: 2004-12-01
• Target enrollment: 0
• Participant gender: All

Summary

• exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction

• cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation

• to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Strasbourg, France

Criteria

Inclusion Criteria:

• Male (> 18 years old) stable heart transplant recipient for at least 6 weeks

• Stable treatment for at least 3 months

• Sedentary people

Exclusion Criteria:

• Unstable cardiac pathology

• Obesity (IMC > 40)

• Participation in another study in the last month

• Chronic renal failure (creatinine clearance < 20 ml/min)

• Renal transplantation

• Diabetes

• Impossibility to practice exercise test

• Nitrate therapy