L-NMMA Dose-response Study in Healthy Subjects

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Regional Hospital Holstebro
• Treatments: omega-N-Methylarginine

Criteria

Inclusion Criteria:

• Healthy males

• Age 18-35 years

• BMI 18.5-30.0

Exclusion Criteria:

• Tobacco or illicit drug use

• Current use of any prescription or non-prescription drugs

• Alcohol abuse

• History of heart failure, lever failure, chronic kidney disease or cerebral insult

• Diabetes

• Clinical or paraclinical signs of infection

• Pathologic ECG

• Ambulatory blood pressure >140/90 mmHg

• Abnormal blood or urin screening tests