LATe Cerclage in High-risk Pregnancies (LATCH)

• Status: Recruiting
• Trial end date: 2027-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Thomas Jefferson University
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• 18-50 years old, pregnant, assigned female at birth

• Singleton pregnancy

• TVU CL ≤25mm between 24 0/7 - 26 6/7 weeks of gestation

Exclusion Criteria:

• Initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed >14 weeks, or cotwin pregnancy loss diagnosed >14 weeks

• Cerclage in situ

• Preterm labor, defined as painful regular uterine contractions and change in cervical dilation

• PPROM

• Active vaginal bleeding

• Suspected intraamniotic infection

• Major fetal structural abnormality or chromosomal disorder

• Placenta previa or accreta

• Other contraindication to cerclage placement

• Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone