LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy Subjects
Status:
Not yet recruiting
Trial end date:
2023-03-31
Target enrollment:
Participant gender:
Summary
Lysergic acid diethylamide (LSD) is used as recreational substance and as a research
substance to study the mind. Recreationally, LSD is typically used in the form of "blotters"
containing LSD tartrate. In research, both LSD base (LSD alone) or LSD salt in the form of
LSD tartrate are used. The oral bioavailability of LSD is not known and LSD alone and LSD as
salt have never been directly compared regarding their equivalence of plasma concentrations
and effects. Because different forms of LSD are used in research it is important to know
their difference or equivalence for correct dosing of LSD. The present study will compare
equivalent doses of LSD base in ethanol orally, LSD tartrate in water administered orally,
LSD base in an orodispersible film administered orally and LSD tartrate in water administered
intravenously, as well as a placebo using a double-blind, randomized, counterballanced
cross-over design in healthy participants.