LTA-guided Antiplatelet Therapy in Interventional Treatment of Intracranial Aneurysms
Status:
Not yet recruiting
Trial end date:
2023-09-30
Target enrollment:
Participant gender:
Summary
The use of intracranial stents broadens the indications for endovascular treatment of
intracranial aneurysms and improves the cure rate, but it also increases the risk of
postoperative ischemic complications in patients. The current standard dual antiplatelet
regimen is considered to be an important method to reduce thrombotic events. However, some
patients are resistant to antiplatelet drugs and have a high risk of thrombotic events. In
actual clinical work, the standards for platelet function testing are not standardized, and
the antiplatelet drug adjustment program also lacks norms and consensus. This study carried
out a multi-center, prospective cluster randomized controlled study to explore whether the
standardized antiplatelet adjustment program guided by LTA detection can reduce the incidence
of ischemic events after stent implantation in patients with intracranial aneurysms. Further
determine and correct the curative effect of the standardized use of antiplatelet drugs in
the treatment of intracranial aneurysm stents, and finally formulate a set of standardized
antiplatelet regimens for aneurysm stents.
Phase:
Early Phase 1
Details
Lead Sponsor:
Beijing Tiantan Hospital
Collaborators:
Beijing Chao Yang Hospital Chinese PLA General Hospital Hebei Medical University Third Hospital Peking University First Hospital Peking University International Hospital Tianjin Medical University General Hospital Xuanwu Hospital, Beijing