Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to assess the effects of oral cannabidiol (CBD; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% THC) subjective, reinforcing, cognitive, and cardiovascular effects. This experiment is expected to reveal CBD's intrinsic effects when combined with placebo marijuana, as well as its ability to modulate the behavioral effects of active marijuana.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA); Steve Sparenborg
• Treatments: Cannabidiol

Criteria

Inclusion Criteria:

• Adults between the ages of 18 and 50.

• Current marijuana use: Minimum of four times per week, 0.5 joints per occasion during the preceding 4 weeks.

• Able to perform study procedures

• Women practicing an effective form of birth control

Exclusion Criteria:

• Female subjects who are currently pregnant or breastfeeding.

• Current, repeated illicit drug use other than marijuana

• Presence of significant medical illness

• History of heart disease

• Request for drug treatment

• Current parole or probation

• Recent history of significant violent behavior

• Major psychiatric disorder