Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Lamotrigine may be effective in reducing pain, numbness, tingling, and other symptoms of peripheral neuropathy. It is not yet known whether lamotrigine is effective in treating peripheral neuropathy caused by chemotherapy.

PURPOSE: This randomized phase III trial is studying how well lamotrigine works in reducing pain, numbness, tingling, and other symptoms of peripheral neuropathy caused by chemotherapy in patients with cancer.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alliance for Clinical Trials in Oncology
• Collaborator: National Cancer Institute (NCI)
• Treatments: Anticonvulsants; Lamotrigine

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of cancer

• Received, or are currently receiving, neurotoxic chemotherapy, including any of the following:

• Taxanes (e.g., paclitaxel or docetaxel)

• Platinum-based compounds (e.g., carboplatin, cisplatin, or oxaliplatin)

• Vinca alkaloids (e.g., vincristine or vinblastine)

• Experiencing pain or symptoms of peripheral neuropathy for at least 1 month attributed to chemotherapy

• Average daily pain rating of at least 4 out of 10 OR

• Peripheral neuropathy at least grade 1 out of 3 using ECOG sensory neuropathy rating

PATIENT CHARACTERISTICS:

Age

• 18 and over

Life expectancy

• At least 6 months

Hepatic

• Bilirubin < 2 times upper limit of normal (ULN)

Renal

• Creatinine ≤ 1.5 times ULN

Other

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No prior allergic reaction or intolerance to lamotrigine

• No extreme difficulty swallowing pills

• No other identified causes of painful paresthesia preceding chemotherapy, including any of the following:

• Radiation or malignant plexopathy

• Lumbar or cervical radiculopathy

• Pre-existing peripheral neuropathy of another etiology, such as any of the following:

• Cyanocobalamin deficiency

• AIDS

• Monoclonal gammopathy

• Diabetes

• Heavy metal poisoning amyloidosis

• Syphilis

• Hyperthyroidism or hypothyroidism

• Inherited neuropathy

• No significant psychiatric illness (e.g., mania, psychosis, or schizophrenia) that would preclude study participation

• Able to complete questionnaires

PRIOR CONCURRENT THERAPY:

Chemotherapy

• See Disease Characteristics

• More than 7 days since prior methotrexate or other dihydrofolate inhibitors

Other

• More than 7 days since prior, and no concurrent use of any of the following:

• Tricyclic antidepressants (e.g., amitriptyline, nortriptyline, or desipramine)

• Concurrent selective serotonin reuptake inhibitors allowed

• Monoamine oxidase inhibitors

• Opioid analgesics

• Anticonvulsants (e.g., gabapentin, topiramate, valproic acid, or clonazepam)

• Adjuvant analgesics (e.g., mexiletine)

• Prior nonsteroidal anti-inflammatory drugs allowed

• Topical analgesics (e.g., lidocaine gel or patch) to the affected area

• Amifostine

• More than 30 days since prior investigational agents for pain control

• No other concurrent investigational agents for pain control