Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Based on the radiobiological findings that accelerated tumor repopulation in nasopharyngeal
carcinoma occurs in the late-course of radiation therapy, the investigators hypothesize that
intensity-modulated radiation therapy(IMRT) with concomitant boost schedule by increasing
daily dose starting at the fifth week after initiation of IMRT might improve tumor control
and decrease treatment toxicities for locoregionally advanced nasopharyngeal carcinoma. The
study is designed to test if late-course accelerated hyperfractionated IMRT can improve the
outcomes as compared with conventionally fractionated IMRT in newly diagnosed patients with
locoregionally advanced nasopharyngeal carcinoma.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Guangxi Medical University
Collaborators:
Guangxi Sci-Tech Office People's Hospital of Guangxi