Study objectives:
- To provide more insight on the modulation of inflammation and matrix degrading factors
in serum and urine by leflunomide in early , active patients with RA and to validate the
sensitivity of DEMRI (Dynamic Enhanced Magnetic Resonance Imaging) in detecting
inflammatory changes in active RA in response to treatment with leflunomide
- Effect of leflunomide therapy on physical function improvement and Quality of life