Leiden Trial In Prevention of Post-Operative ThromboEmbolic Events
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
In neurosurgical patients, the risk for venous thromboembolic events (VTE) is high due to the
relatively long duration of surgery, the high occurrence of prolonged immobilization of
patients due to paresis of the legs or intracranial pathology causing inability to mobilise2.
Moreover, intracranial and intraspinal tumours and subarachnoid haemorrhage cause
hypercoagulability, which increases the risk on VTE. There is a high degree of diversity in
attributed risk on thrombosis in the neurosurgical patient cohort. Due to this diversity,
insufficient power of performed studies and lack of careful phenotyping and description of
risk factors in previous studies on deep venous thrombosis (DVT) prophylaxis, as yet the
optimal DVT prophylaxis in neurosurgery remains unclear. A prospective randomized study with
adequate power and detailed information on patient related factors (malignancy, subarachnoid
haemorrhage, prevailing coagulopathies), type of surgery, duration of surgery, and
postoperative immobilisation will allow us to identify the optimal treatment strategy for
high risk neurosurgical patients.
In the current study all patients that fulfil the inclusion criteria will be subjected to
post-operative systematic evaluation of VTE by echo-duplex investigation.