Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy

• Status: Completed
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The objectives of this clinical study were to:

1. Assess the influence of Lepidium sativum in situ gel versus simvastatin gel on the clinical parameters in periodontitis patients as the primary objective.

2. Detect the effect of locally delivered Lepidium sativum and simvastatin gels on the nuclear factor kappa B (NF-κB) level in gingival crevicular fluid as the secondary objective.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• Patients with ages ranging from 25 to 50 years old.

• Localized periodontitis, probing depth ≥5 mm. Less than 30% of teeth are involved.

• Both genders.

• Patients must be able to return for the recall visits and agreed to sign the written consent after a full explanation of the study.

• Systemically free according to the American Society of Anesthesiologists (ASA I).

Exclusion Criteria:

• Smokers

• Pregnant and lactating women or oral contraceptive usage

• Prisoners or abused individuals

• Unwilling patients to perform oral hygiene measures of plaque control.

• Patients with a history of allergy against any components of the two materials.

• Previous Periodontal treatment or any use of antibiotic/anti-inflammatory drugs within the last 6 months before the initiation of the study.