Leptin and Endothelial Function

• Status: Completed
• Trial end date: 2004-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this trial was to determine if injections of leptin would improve vascular function in normal-weight, healthy volunteers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Collaborator: Amgen

Criteria

Inclusion Criteria:

• Healthy male or female ages 18-50.

• BMI < 27 kg/m2 for lean group

Exclusion Criteria:

• Any CVD risk factor (diabetes or fasting glucose > 126 mg/dL

• Hypertension or measured BP > 140/90 mmHg

• Current tobacco smoking within last month

• LDL>160 mg/dL, HDL<35 mg/dL)

• Renal insufficiency (creatinine > 1.4 mg/dL)

• Thyroid abnormalities (abnormal TSH)

• Established CVD (any atherosclerosis, or history of peripheral arterial disease, previous stroke, myocardial infarction, angina, heart failure, aortic aneurysms)

• Usage of medications which impact endothelial function within last month (folate, fish oil, Vitamin C or E, L-arginine, blood pressure or lipid-lowering medications, diabetes medications)