Letrozole Versus Gonadotropins in Clomiphene Citrate Resistance

• Status: Completed
• Trial end date: 2019-10-31
• Target enrollment: 0
• Participant gender: Female

Summary

Clomiphene citrate resistance (CCR) occur in 15-40% in women with PCOS. Several studies have shown that letrozole is superior to CC regarding side effects, ovulation, and pregnancy rates. Letrozole or gonadotropins use for ovulation induction in CCR is not well established which is superior and most safe.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Letrozole

Criteria

Inclusion Criteria:

• Infertility lasting one year or more in presence of regular intercourse,

• Patients' age between 20-35years

• Normal semen analysis according to WHO 2010

• Patent fallopian tubes (e) Normal prolactin and TSH.

• Anovulatory cycles confirmed by mid-luteal progesterone ≤ 3 ng/ml and

• Clomiphene citrate resistance for 3 cycles of 150mg.

Exclusion Criteria:

• Any hormonal disturbances eg. hyperprolactinemia,

• Immunological causes of infertility,

• Coital errors,

• Metabolic disorders and

• Poor patient compliance.