Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.
Status:
Not yet recruiting
Trial end date:
2023-11-01
Target enrollment:
Participant gender:
Summary
One of the indications of freezing is to reduce the risk of ovarian hyperstimulation syndrome
particularly in polycystic ovarian disease (PCOS) women. Very few RCTs addressed the issue of
optimizing the endometrium for a frozen cycle. Interestingly, Letrozole for ovarian
stimulation showed significantly better reproductive outcome when compared with hormone
replacement therapy (HRT) cycles. In addition, HRT cycle has been associated with higher
miscarriage rate when compared with natural cycle frozen embryo transfer. Nevertheless, there
is not yet a well-designed prospective randomized study comparing letrozole and HRT in PCOS
women undergoing frozen embryo transfer.