Tubal ectopic pregnancies are abnormal pregnancies in the Fallopian tube, rather than in the
womb. They occurred in around 1-2% of all pregnancies. Methotrexate (MTX) given by the
intramuscular route i.e. systemic, a commonly used drug for cancer , was a widely used
alternative for management for unruptured tubal ectopic pregnancies and was recommended as
first line treatment for selected women.
Letrozole, aromatase inhibitor, can suppose oestradiol level. Combination of letrozole with
misprostol has shown to improve the complete abortion rate in miscarriage. As a result,
addition of letrozole may cause a higher success rate in the medical treatment of ectopic
pregnancy.
As the evidence of combination of MTX and letrozole in tubal ectopic pregnancies is not
available, the objective of the present study is to evaluate efficacy of combination of MTX
and letrozole in women with tubal ectopic pregnancies