Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Leukotrienes play critical roles in the inflammatory process in allergic rhinitis and bronchial asthma, therefore, anti-leukotriene therapy is part of treatment for asthma. However, not all allergic rhinitis accompanied with or without asthma treated with anti-leukotriene were effective. So it is critical to develop a method to identify the response subgroup. In this study, it is assumed that nasal physiological responsiveness to leukotriene nasal provocation test (NPT) is able to gain evidence on the effect of leukotriene on the development of allergic rhinitis and asthma, and is helpful to the use of anti-leukotriene agent. The purpose of the study is to establish the methodology and diagnostic value of leukotriene D4 (LTD4) nasal provocation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Guangzhou Institute of Respiratory Disease
• Treatments: Histamine; Histamine phosphate

Criteria

Inclusion Criteria:

• Patients with allergic rhinitis accompanied with or without asthma

• positive skin prick test (SPT)

• had no acute upper or lower airway infection 2 weeks prior to study

• no oral or nasal anti-histamines

• no leukotriene receptor antagonists for 1 week

• no oral or nasal and inhaled corticosteroids for 2 weeks

Exclusion Criteria:

• smokers

• a past confirmed history of chronic respiratory disease other than asthma

• other severe systemic diseases (myocardial infarction, malignant tumor, etc.)

• under immunotherapy

• unable to complete the test or had limited understanding

• pregnancy