Overview

Leuprolide in Determining the Cause of Gonadotropin Deficiency

Status:
Completed
Trial end date:
1998-09-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: The body's response to one injection of leuprolide may provide more information than the standard test for gonadotropin deficiency in determining whether the cause of gonadotropin deficiency is related to the hypothalamus or the pituitary gland. PURPOSE: Randomized double-blinded clinical trial to study the effectiveness of leuprolide in determining the cause of gonadotropin deficiency.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Chicago
Treatments:
Hormones
Leuprolide
Criteria
PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

- Prepubertal children with constitutionally delayed puberty At least 2 years
retardation of bone age Spontaneously progress into puberty within 1 year Boys: Testes
long diameter 2.5-3.5 cm and plasma testosterone 40-300 ng/dL Girls: Breast
development, but premenarcheal OR Hypogonadotropinism Delayed onset of pubertal
milestones associated with anterior panhypopituitarism OR Kallman's syndrome No
spontaneous progression into puberty within 2 years after 6 months replacement sex
steroid treatment

--Prior/Concurrent Therapy--

- At least 2 months since prior sex hormone treatment

--Patient Characteristics--

- Age: 14-18 for children with hypogonadotropinism 9-13 for normal children

- Other: No chronic systemic disease No metabolic disease No endocrine disease No growth
hormone deficiency