Levetiracetam Prophylaxis in Brain Tumor Resection Pilot

• Status: Not yet recruiting
• Trial end date: 2024-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate feasibility of a double-blind randomized controlled trial for levetiracetam prophylaxis for prevention of seizure in the perioperative phase of brain tumor resection.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hamilton Health Sciences Corporation
• Collaborator: McMaster University
• Treatments: Levetiracetam

Criteria

Inclusion Criteria:

• Adult age 18 years or older

• Undergoing craniotomy for a brain tumor

• Intra-axial tumor location

• Supratentorial tumor location

Exclusion Criteria:

• Documented seizure history or epilepsy diagnosis

• Currently taking an antiepileptic medication

• Unable to take levetiracetam (e.g. allergy, inability to swallow)

• Inability to obtain consent from participant or substitute decision maker prior to surgery

• Renal impairment with eGFR less than 50

• Pregnancy