Levetiracetam for Painful Polyneuropathy

• Status: Completed
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Polyneuropathy of different etiologies is often associated with pain. The standard treatment of this pain is anticonvulsants or antidepressants, but none of these treatment are effective or tolerable for all patients. Levetiracetam is a newer anticonvulsant and it is the hypothesis is that it could relieve neuropathic pain in polyneuropathy. This is a randomised, double-blind, placebo-controlled, cross-over trial on the effect of levetiracetam 3.000 mg/day on pain in polyneuropathy

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Odense University Hospital
• Treatments: Etiracetam; Levetiracetam; Piracetam

Criteria

Inclusion Criteria:

• age 20 to 0 years

• painful symptoms of polyneuropathy for at least 6 months

• confirmed diagnosis of polyneuropathy

• baseline pain score of 4 or more (0 to 10 point scale)

• pain at least 4 days a week

• adequate anticonceptive treatment for women with childbearing potential

• informed consent

Exclusion Criteria:

• other cause of pain

• previous allergic reactions towards levetiracetam

• known adverse drug reactions on levetiracetam

• pregnancy

• severe disease

• inability to follow study protocol

• treatment with antidepressants, other anticonvulsants or opioids