Levofloxacin Concomitant Versus Levofloxacin Sequential

• Status: Not yet recruiting
• Trial end date: 2027-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this trial is to determine the efficacy of levofloxacin based sequential treatment regimen or concomitant levofloxacin based regimens as empirical first-line therapy in the Syrian population

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Damascus Hospital
• Treatments: Amoxicillin; Esomeprazole; Levofloxacin; Metronidazole

Criteria

Inclusion Criteria:

• Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods:

• Positive rapid urease test (CLOtest).

• Histologic evidence of H. pylori by modified Giemsa staining.

• Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.

Exclusion Criteria:

• Children and teenagers aged less than 18 years.

• Previous eradication treatment for H. pylori.

• Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics.

• History of gastrectomy.

• Gastric malignancy, including adenocarcinoma and lymphoma,

• Previous allergic reaction to antibiotics (Amoxicillin, Tinadizole,

• Doxycycline,Bismuth subsalicylate,) and prompt pump inhibitors (Es- omeprazole).

• Contraindication to treatment drugs.

• Pregnant or lactating women.

• Severe concurrent disease.

• Liver cirrhosis.