Levothyroxine (L-T4) Absorption After Bariatric Surgery

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Intestinal absorption of levothyroxine (LT4) tablets depends on its dissolution in gastric acid secretion, which is reduced after bariatric interventions. Impaired LT4 absorption due to low gastric dissolution has been reported in patients with atrophic or chronic gastritis. The objective of this study is to evaluate the absorption of LT4 tablets in morbidly obese patients before and after Roux-en-Y bariatric surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo

Criteria

Inclusion Criteria:

• morbidly obese individual (body mass index (BMI)≥40 Kg/m2)

• individuals for whom bariatric surgery is indicated

• patients who had undergone Roux-en-Y bariatric surgery 2 to 3 months before inclusion in the study

Exclusion Criteria:

• previous diagnosis of thyroid cancer

• diabetes mellitus in use of insulin

• chronic or atrophic gastritis

• use of medications associated with impaired LT4 absorption.