Licorice Botanical Dietary Supplements - Metabolism and Safety in Women
Status:
Active, not recruiting
Trial end date:
2021-12-30
Target enrollment:
Participant gender:
Summary
Human safety studies will be carried out to test whether red clover botanical dietary
supplements used by peri- and post-menopausal women are safe to use with Food and Drug
Administration (FDA)-approved drugs. To test this, a red clover dietary supplement
(previously tested in women at the University of Illinois at Chicago without any harmful
effects) will be given with four selected FDA-approved drugs to determine if the Licorice
supplement can increase or decrease how these medications are absorbed, metabolized and
excreted by the human body. Preclinical studies predict that the licorice supplement might
affect the metabolism or break down of these probe drugs.