Lidocaine Before Esophageal Manometry and Ambulatory pH Monitoring

• Status: Completed
• Trial end date: 2020-08-05
• Target enrollment: 0
• Participant gender: All

Summary

A randomized controlled trial comparing esophageal manometry and ambulatory pH monitoring test tolerance in the presence versus in the absence of topical lidocaine.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

Adult patients undergoing esophageal manometry or ambulatory pH monitoring at our center who are able to read and consent to participate in the study.

Exclusion Criteria:

• Patients < 18 years

• Incapacity to provide consent

• History of lidocaine allergy

• Current pregnancy

• Previous esophageal manometry or ambulatory pH monitoring in the last 14 days

• Previous participation in the study

• Severe cirrhosis (Child-Pugh C)

• Severe chronic kidney disease (eGFR<30 mL/min/1.73m2)

• Severe heart failure (New York Heart Association Functional Classification 3-4)

• Severe respiratory failure (dyspnea or oxygen-dependent at rest)

• Any active severe incapacitating chronic or acute medical disease

• Active hospitalization

• Ulcerated, atrophic, infected or recently burned (in the last 30 days) nasopharynx

• Recent surgery involving the nasopharynx (in the last 30 days)

• Severe chronic pain (ex. regular daily use of opioids)

• Previous stroke or any neurological lesion with resulting current sensory deficit

• Major neurocognitive disorder

• Any active severe incapacitating chronic or acute psychiatric disease