Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary hypothesis is that esmolol and lidocaine, when given without the use of a tourniquet, provide relief of propofol injection pain that is superior to placebo when assessed using the propofol pain scoring tool

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Treatments: Esmolol; Lidocaine

Criteria

Inclusion Criteria:

• 18-60 years of age

• ASA 1-3

• Elective surgical procedure

Exclusion Criteria:

• BMI ≥ 45

• Pregnancy

• Requirement for RSI or awake intubation

• Suspected or known difficult airway

• Contraindication to IV in either upper extremity

• Chronic pain syndrome including fibromyalgia

• Use of opioids, NSAIDs, or other analgesics within 24 hours (including preoperative PO Celebrex, Lyrica, Tylenol, etc.)

• Any use of opioids in the past three months

• Significant cardiopulmonary or hepatic dysfunction

• Hypersensitivity to study medications