Lidocaine Infusion or Quadratus Lumborum Block and Intrathecal Morphine, Versus Intrathecal Morphine Alone

• Status: Terminated
• Trial end date: 2021-05-04
• Target enrollment: 0
• Participant gender: Female

Summary

This study may provide evidence for whether or not systemic lidocaine infusion offers significant advantage over truncal regional blocks in gynecology oncology surgery patients in terms of post-operative analgesia, recovery, and safety profile. Further, it may show whether there is any increased efficacy of adding truncal regional block or systemic lidocaine versus intrathecal opioid administration alone.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Lidocaine; Morphine

Criteria

Inclusion Criteria:

• Adult patients undergoing gynecologic-oncology surgery involving a mid-line laparotomy incision and as part of the local ERP, who are initially identified as an outpatient

• 18 years of age or older

Exclusion Criteria:

• Pregnancy,

• BMI>45,

• Age >70,

• Actual weight <65 kg

• Severe COPD

• Severe asthma

• Other severe respiratory disease (ILD, etc.)

• Local anesthetic allergy

• History of cardiac arrhythmia or heart block

• CHF

• Use of oral anti-arrhythmia agents or lidocaine analogues (i.e. mexiletine)

• Inability to be a candidate for intrathecal opioid injection based on medical history and provider judgement