Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain

• Status: Terminated
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

The investigators are conducting this study to find out if intravenous (injected through the vein) infusion of lidocaine and ketamine administered with general anesthesia is as effective as a paravertebral block in lessening pain after surgery and that both of these techniques are superior to general anesthesia alone in reducing pain immediately after surgery and in the long-term.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Outcomes Research Consortium; The Cleveland Clinic
• Treatments: Fentanyl; Ketamine; Lidocaine; Midazolam; Ropivacaine

Criteria

Inclusion Criteria:

• Age greater than 18 and less than 75 years

• Male

• Unilateral inguinal hernia scheduled for elective open repair

Exclusion Criteria:

• Incarcerated hernia or urgent procedure

• Reoperation (recurrent hernia)

• Contraindication to regional anesthesia such as:

• Coagulopathy

• Infection at the site of needle insertion

• Pre-existing chronic pain (at any site) requiring treatment

• Contraindication to any study medication (local anesthetic or ketamine)

• History of significant Axis I psychiatric disease (major depressive disorder,bipolar disorder, schizophrenia, etc.)

• Significant hepatic (ALT or AST > 2 times normal) or renal (serum creatinine > 2 mg/dl) impairment