Background and Objectives: Fibromyalgia is a pain syndrome characterized by numerous
manifestations. The objective of this study was to evaluate the effect of the combination of
intravenous lidocaine and amitriptyline on the manifestations of fibromyalgia. Methods: A
prospective, randomized, double-blind, comparative study was conducted. All patient received
25 mg amitriptyline. Patients of group 1 (n = 15) received 125 mL 0.9% saline, and patients
of group 2 (n = 15) received 240 mg lidocaine in 125 mL 0.9% saline once a week for 4 weeks.
Manifestations were recorded before and 4 weeks after treatment. Pain intensity was rated on
a verbal numerical scale.