Lifestyle Modification and Metformin Use in the Treatment of HIV
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
A healthy diet and exercise have improved the health of people without human immunodeficiency
virus (HIV) who have Metabolic Syndrome. In this study we would like to find out if the same
benefit can be seen in people with HIV and Metabolic Syndrome. Patients with Metabolic
Syndrome usually have a large waist, high blood cholesterol levels, high blood pressure, and
high blood sugar levels. These are risk factors, which may increase one's chance of
developing heart disease and/or diabetes. The purpose of the study is to evaluate the effects
of different methods of treating HIV associated Metabolic Syndrome. The groups are: 1) a
lifestyle modification program plus metformin (also known as glucophage), 2) lifestyle
modification plus placebo, 3) metformin alone or 4) placebo alone. The lifestyle modification
program consists of nutrition and exercise sessions with the goal of improving body
composition, heart health, and ways to lower the risk of developing diabetes.
Phase:
N/A
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)