Lignocaine Only Versus Lignocaine Plus Magnesium Sulphate for Pain Relief After Episiotomy.
Status:
Not yet recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
Trauma to perineal area is one of common problems faced by obstetricians affecting physical,
social and mental wellbeing of patients. During labor, surgical incision to perineum
(episiotomy) is done to facilitate delivery of fetus. Episiotomy is associated with
complication such as hemorrhage, infection, pain and wound breakdown. Pain relief after
episiotomy is primary concern of obstetrician and right of patient. Pain after delivery
causes delayed mobility of patient, late initiation of breast feeding and may affect mother
psychologically. Magnesium sulphate is readily available in obstetric units due to its
diverse uses, wide safety margins and cost-effectiveness. Magnesium is a calcium channel
blocker and noncompetitive N methyl D aspartate (NMDA) receptor antagonist with
anti-nociceptive effects. Blocking of NMDA receptors inhibits central sensitization due to
peripheral nociceptive stimulation. The role of magnesium has been evaluated as adjuvant for
intra- and post-operative pain relief in orthopedic, gynecological, and thoracic surgeries
and has established role in anesthesia and obstetrics. Lignocaine given locally does not
provide adequate pain relief. There is need to find adjuvants to local anesthesia for pain
relief after episiotomy. There is paucity of published data on the use of Magnesium sulphate
as an adjunct to local anesthetics for episiotomy or its repair. No local study has been done
in this regard.