Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers

• Status: Completed
• Trial end date: 2018-02-22
• Target enrollment: 0
• Participant gender: All

Summary

This randomized phase I trial studies the side effects and best dose of linaclotide acetate in preventing colorectal cancer in healthy volunteers. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of linaclotide acetate may prevent colorectal cancer.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: National Cancer Institute (NCI)
• Treatments: Linaclotide

Criteria

Inclusion Criteria:

• PRE-REGISTRATION INCLUSION CRITERIA

• Ability to understand and willingness to sign a written informed consent document and follow study procedures

• Willingness to abstain from grapefruit juice, alcohol, and concomitant medications during study

• Willingness to employ adequate contraception for men and women of childbearing potential; acceptable methods include double barrier methods, intrauterine device (IUD), postmenopausal status documented by serum follicle-stimulating hormone (FSH), and/or documentation of surgical sterilization

• Body mass index < 35 kg/m^2

• Willingness to provide blood and tissue specimens for research purposes

• REGISTRATION INCLUSION CRITERIA

• Participants must have normal organ function and have normal laboratory findings without clinically significant findings

• Satisfactory anesthesia and intestinal preparation, with no findings of advanced adenoma, chronic inflammation, or cancer

Exclusion Criteria:

• PRE-REGISTRATION EXCLUSION CRITERIA

• Previous personal history of advanced adenomas (>= 1 cm in maximal diameter, >= 3 in total number, villous morphology, or high-grade dysplasia) or colorectal cancer

• Family history of polyposis syndrome (e.g., familial adenomatous polyposis [FAP], hereditary non-polyposis colorectal cancer [HNPCC]) or colorectal cancer (first degree relatives younger than 60 years old)

• History of gastroparesis

• History of surgery involving the luminal gastrointestinal (GI) tract, including bariatric surgery

• History of celiac disease

• Inflammatory bowel disease (Crohn's disease, ulcerative colitis)

• Irritable bowel syndrome, chronic constipation, functional bowel disorders, or colonic motility disorder

• Any malignancy within 3 years of baseline; participants with a history of basal cell or squamous cell skin cancer may be enrolled at the discretion of the investigator

• Participants may not be receiving any other investigational agents

• History of allergic reactions attributed to compounds of similar chemical or biologic composition to linaclotide

• History of difficulty with colonoscopy or abnormal colorectal anatomy

• Uncontrolled current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

• Pregnant or lactating women

• Use of laxatives more than 3 times per week

• Intestinal motility agents, histamine-2 inverse agonists (H-2 blockers), or proton pump inhibitors

• Current use of >= 5 cigarettes/day

• Current use of >= 3 alcoholic drinks/day

• Use anti-platelet agents within two weeks of anticipated colonoscopy

• Use of anti-coagulants within two weeks of anticipated colonoscopy

• History of bleeding/coagulation problems

• Prior intolerance of or contraindications for the use of sedation or anesthetic agents, which would prevent the safe use of sedation for colonoscopy; this includes allergies to eggs and soy products

• Any medical condition judged by the investigator to constitute a risk to safe participation

• REGISTRATION EXCLUSION CRITERIA

• Colonoscopic finding requiring clinical intervention

• Use of any illicit or illegal substances detected by urinary drug screen

• Inadequate pre-intervention bowel preparation, as determined by the study physician