Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

• Status: Not yet recruiting
• Trial end date: 2023-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Through this pilot prospective trial, we aim to obtain preliminary data investigating the effectiveness of perineural catheters and liposomal bupivacaine, both currently accepted as standard care at Maine Medical Center, for the management of post-limb amputation pain. We will use the data that we collect to inform the design of a larger, appropriately powered study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ryan Mountjoy, MD
• Collaborator: MaineHealth
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists Physical Status Classification I-IV

• Scheduled for primary amputation or stump revision

• English speaking

Exclusion Criteria:

• Patients unable to cooperate or consent to the study

• Allergy to local anesthetics

• Existing infection at planned needle insertion site

• BMI > 40kg/m2

• Patients with a history of coagulopathy

• Emergency amputations

• Contralateral amputations

• Patients with a substance use disorder diagnosis

• Patients on opioids >90 morphine milligram equivalents (MME)/day