Liraglutide Efficacy on Glucocorticoid Induced Hyperglycemia in Patients High Risk for Diabetes

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Glucocorticoids therapy exposes the patient to an increased risk for diabetes morbidity. However, there is no proven preventive therapy. GLP-1-RA has shown to improve glucose metabolism in healthy volunteers treated with glucocorticoids. We assume that GLP-1-RA will improve glucose metabolism in patients with high risk for diabetes morbidity, treated with glucocorticoids.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rabin Medical Center
• Treatments: Liraglutide

Criteria

Inclusion criteria:

• Planned treatment with T. Prednisone in dosage >0.5 mg/kg for two weeks or more.

• Age >18 years

• Body mass index >27 kg/m2 OR 1st degree relative with type 2 diabetes mellitus OR hypertension OR hyperlipidemia OR gestational diabetes in the past OR diagnosis of polycystic ovary syndrome.

Exclusion criteria:

• Glycosylated hemoglobin A1c >6.5%

• Diagnosis of diabetes mellitus or treatment with anti-glycemic drug

• Pancreatitis (acute or chronic) in the past

• Active malignancy

• Medullary thyroid carcinoma or multiple endocrine neoplasm type 2 of the patient or of 1st degree relative

• Pregnancy